V for Vitrification # A to Z Challenge

DISCLAIMER

Vitrification in IVF can allow freezing of spare embryos with better post-thaw survival rates and higher pregnancy and live birth rates from frozen embryo transfer cycles. In simple terms Vitrification means freezing the embryos and also oocytes /eggs, for later or future use.

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vitrification is a solid glass-like cell, free of ice crystals.Vitrification can efficiently preserve spare eggs and embryos, so they can be used later on to achieve a pregnancy after thawing. Survival rates after vitrification and subsequent pregnancy rates are much better than they were with conventional slow freezing.

Vitrification is dependent on the placement of the oocyte/embryo in a very small volume of vitrification medium which is then cooled at an extreme rate, so that the embryos are flash frozen and preserved intact,content source, here.

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PS:I am not a doctor, these are just my findings, my experiences and my infertility warrior friends experiences,which are a part of my life. I am half doctor myself because we go though so much,sometimes I feel I know my diagnosis better than my RE(Reproductive Endocrinologist). Hope these posts make some sense for people who are not a part of this journey.This post is a part of #AtoZchallenge2018.

P for Progestrone & PGS #A to Z Challenge

DISCLAIMER

Progesterone is a hormone usually used in HRT cycles , progesterone is also used for other women reproductive issues too but I do not have much idea about it .Progesterone is a steroid hormone released by the corpus luteum that stimulates the uterus to prepare for pregnancy, if the pregnancy does not happen, the women gets her period and the endometrial lining sheds, and starts the period next cycle.

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If a women falls pregnant the progesterone helps in keeping the pregnancy. In IVF pregnancies  progesterone is given even before embryo transfer, like if its a day 3 transfer 3 days of progesterone pessaries or progesterone injections, sometimes both are given, then transfer is done. If its is a day 5 transfer five days of progesterone is given, after the transfer is done until, 10 to 12 weeks women need to take those progesterone suppositories, later the embryo produces its own progesterone, I am taking about IVF pregnancies.If their is any wrong in the information I have written here do correct me, if anybody has read this post.

PGS  or pre-implantation genetic screening, is a genetic test performed on embryos produced through IVF. PGS gives information about embryos’ genetic health to help your embryologist select the best embryo for transfer and improve your chance of achieving a successful pregnancy.In simple terms, few cells are taken/biopsied  from  the already formed embryos to check if it has any chromosomal or genetic problem, and then the best embryo is selected and transferred, in the next FET cycle. PGS is usually done  only when their are persistent implantation failures, abnormal growth of embryo and miscarriages.

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PGS  test is not suggested for all. PGS is a very expensive test. In my friends case which I have written about here, she had to abort her em-baby by taking oral pills,because her baby was growing on time and their was not heartbeat, so her doc told before going the PGS test, let her do a a bit less expensive blood test for both her and husband ,its called Karyotyping which I have written here, if that test comes normal she can go head with her next FET or if their is some chromosomal problem in either one of her or her husband, then they have to go for PGS.

FYI :This  above post is a little about what I know due to the infertility treatments,and some is via the always great google search, resource.


 

PS:I am not a doctor, these are just my findings, my experiences and my infertility warrior friends experiences,which are a part of my life. I am half doctor myself because we go though so much,sometimes I feel I know my diagnosis better than my RE(Reproductive Endocrinologist). Hope these posts make some sense for people who are not a part of this journey.This post is a part of #AtoZchallenge2018.

 

 

K for karyotype #A to Z Challenge

DISCLAIMER

I was thinking what should I write for K, there are simple terms , its all about my feelings like my last and few other posts. I was wondering what will I write for K, then my friend F about whom I have written here, here and much more times. I was talking to my friend yesterday, she had gone for her check up after her miscarriage/abortion after her first transfer, she had to do a series of tests to rule out problems before her next transfer.

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My friend’s RE suggested many types of test as I said above, but one test called Karyotype/karyotyping  was suggested for both her and her husband,I wanted to know about it. I thought I should write about Karyotype test  here, this post might help people who gone through miscarriage/abort the baby due to no proper growth of the baby,or no on time growth of the baby, or no heartbeat on the give time frame,that’s what my friend did, took some pills and miscarry the baby and it was devastating for all of us.

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Karyotype test is for both her and her husband, the report will be known after three weeks, and that waiting period is a mental torture . Karyotype is one of the expensive tests to know about the chromosomal problems, but that’s not the end of the tests. If my friends tests comes normal, she is good to go for the next transfer, if not then she has to do PGS test on the embryos,more about PGS test in my future posts, din’t I say infertility sucks, will update about the test result after my friend gets the result and how her RE interpreted it.


PS:I am not a doctor, these are just my findings, my experiences and my infertility warrior friends experiences,which are a part of my life. I am half doctor myself because we go though so much,sometimes I feel I know my diagnosis better than my RE(Reproductive Endocrinologist). Hope these posts make some sense for people who are not a part of this journey.This post is a part of #AtoZchallenge2018.

E for Expectations # A to Z Challenge

DISCLAIMER

We infertility warriors have loads of expectations with the treatment, obviously we have all the right to have expectations isn’t it,because with all the promises , guarantees and the money we invest, yes I call it investment.The infertility treatments are emotionally, physically and financially draining, but we go thought it because we genuinely  expect what is promised, that too the most wanted .When we start our infertility journey we think finally we will be getting answers, for why the hell we are not able to conceive.We will get few answers few even the doctor will not be able to tell, even the modern science does not have answers for certain things.

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When we started the treatment, I can specifically talk about IVF journey cause I am going through it right now, there different types of protocols and treatment depending upon each person and their issues regarding infertility.

So coming back to the topic when I told that I can have my own baby with IVF procedure I was on cloud nine, I was expecting this from my doctor, because I dint want any other procedure, which does not have that much success rate compared to IVF, IVF too has just 40 to 70 percent depending on each person, but better success rate then other procedures, so obviously we will have the exceptions, but these exception can give u a big jolt when things don’t turn out the way you want it to be or the way it was promised,

My friend who had IVF procedure almost same time as me, she got pregnant in  first transfer (FET)itself but had to miscarry because the fetus was not developing and no heartbeat,one more friend her embryos dint survive at until day 5 , she has to to 2nd round of IVF go through all the drill all over again, many more sad stories about people who i know who go through infertility, and about me my embryos are frozen, my endometrial lining is not growing according to my RE’s satisfaction, so from January my embryo transfer is being  postponed, she has some plan this month hopefully it will work for me,  all my expectations are gone in the drain, but we are normal humans, we cant stop having exceptions again an again and be disappointed, this is infertility life.

B for Beta HCG # A to Z challenge

DISCLAIMER

Beta HCG  is the word for A to Z challenge,Beta hcg is never the beginning in the infertility journey nor the ending its somewhere in between, all B’s here, but it is one of the important tests to know if your pregnant, also  to know how the pregnancy is progressing, when the number are doubling  or their is increase in the hcg level in the blood after every 48 to 72 hours . Beta hcg is a blood test/work after the dreaded two week wait (tww) to know if your pregnant or not. TWW is usually after your natural  timed cycle,clomid cycle , IUI , IVF , FET cycle and much more difficult cycles, where you little embryo is formed and you will know if its growing and stuck to the uterus, after the tww that is approximately 14 to 15 days depending  after clomid, natural, IUI cycles and in IVF cycle depending on the day of the embryo like day 3 embryo and day 5 embryo transfer.

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I know this is all complicated but this just the beginning not ending after positive pregnancy test. The hcg level in your blood should be good if not ok, then the numbers should double, after a week the embryo should grow, later after another week heartbeat should be detected and its its never ending until we hold the baby, these infertility treatments are never ending and their is no success guaranteed after all the physical, mental and financial drain.

PS:I am not a doctor, these are just my findings  and experiences which I have know because of this infertility journey, I am half doctor myself because we go though so much,sometimes I feel I know my diagnosis better than my RE(Reproductive Endocrinologist), also for B this is the best word I knew for the #AtoZchallenge, hope people have understood my post, if at all anyone has read.

 

 

 

THE LINING SAGA

DISCLAIMER 

I don’t know what will happen with my first FET cycle,usually my lining is never a issue, its always thickens on time, this is the first time, it is not getting thick, it is triple line from day 10 but not thickening like it has too.I don’t know why, I was checking my clomid cycle file, where I had to go for alternate days for scans from day 14/15/16 until I ovulate, in all those  scans every two days it used to grow 1 mm, like on day 15 it would be 6 mm and on 17 it would be 7 mm like that, so it would grow fine by the time I would ovulate, but why this time with all the medication I don’t know, this is very frustrating.

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On my day 15 scan I went for the scan it was just 6.4 or 6.6 mm not sure, in those five days it just grew less than 1 mm, why oh why is this happening.So my RE told me that my lining is not growing according to her satisfaction, so she gave me a choice to either cancel this cycle or wait for two three days and checking if my lining is growing and then decide , I told we will wait and check after two days, so now my scan is on 25th day 18 and I am hoping that it grows by then and but I am not sure.RE also told that sometime they cancel 2 to 5 cycles until the lining is fine, because our embryos are very important, we can can cancel due to lining but we  should not lose embryos and I agree with that.

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My IVF cycle from the start as always been very slow, loads of confusions, waiting and never ending suspense until  the end. I am really feeling very low and don’t know what next, if my cycle gets cancelled  luckily we had planned a trip for our anniversary but we had not cancelled don’t know why so we will go ahead with the trip in case the cycle is cancelled, so I guess I have something to look forward and divert my mind, also hopefully RE will start the FET immediately form next cycle itself I cant wait any more, already I am very frustrated with this cycle and I am also hoping this cycle wont be cancelled but I am ready for whatever it is and trying to be calm.I am tired of waiting.

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IVF – Part 4

DISCLAIMER

Happy new year to all my readers, have a great year ahead and hope all dreams come true and hold out babies soon. All the TTC ladies are in my prayers.I still can’t believe its 2018. Last Jan when I was in the middle of the infertility treatment, I was still in those beginning phase of the treatment and was so sure will conceive in one of those clomid or one of the IUI’s, but the universe had some other plans I guess. As I type this, still there is no baby in my belly. I could have been PUPO(Pregnant Until Proven) by yesterday but I asked my RE for day five transfer.

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Ok coming back to the part 4 of out IVF, on 29th  Dec 2017 on the auspicious day of Vaikunta Ekadhasi according to our Hindu calendar, my egg pick up/retrieval (ER) was done by 1.30 pm, according to my trigger shot timings of 35 to 36 hours.I was praying that I should get at least 12 to 15 eggs, but we got only 10.In the morning before ER BH had to give fresh SA, but he had to give it soon , as he had some important meeting , so there was so much confusion but finally the embryologist agreed to give it sooner and BH gave the fresh sample left, even though there was frozen back up, that morning confusions was very taxing.

After the ER , when I woke up, RE came up to me and told that they got 10 eggs, lets see how the fertilization is, we will know about it tomorrow and went away before I could ask any questions.I was very angry about myself that I got only 10, by then my friend F came to meet me,  about whom I have mentioned   here and here. My friend told why are you even feeling bad when others don’t even get a egg or more less than yours, I was like I am worried about me I din’t want to compare  myself with anyone at that point.Anyways I felt better speaking to her.

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When I was declared fine by the duty doctor to go home,RE had  prescribed some tabs until I meet her on Monday day 3, seeing those tabs , my friend F told you might have fresh transfer, I was like it cant be, but those tabs were for readying me for the fresh transfer. I was confused and shocked cause I had prepared myself mentally for FET. I have written about it here so many times.I am on vaginal progesterone and one more tab I don’t know the name the other tablet for preparing for ET, those tabs are making me feel confused, heart burn,nauseous and very tired.

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I left the clinic praying all of our  eggs to be fertilized and not to think about the ET (Embryo Tranfer). Until the next day I was so darn nervous, until I got to know about our fertiliation. The report was 9 eggs were mature and 7 had fertilized, that was a ok news o me, I was ok fine. Then prayed that they all grow fine, praying was the only choice I had, that’s what I did on the last weekend of 2017.

Monday JAN 1 st 2018, I went to the clinic, the junior doc did the scan, she told my lining is good and after ER there was some fluid  in the utreus, that fluid was also not there everything was looking good , so they wanted me to do day three transfer.I was not able to react, I asked can we do day 5 transfer, the blastocyst transfer,they were like we will check with RE and then decide.

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I met the RE she was busy with ER with other patients, she said.She told that success rate does not vary much, most of my patients have had success with day 3 transfer, decide what you want and called the embryologist. The embryologist showed me the report, all 7 were going good on day 3,only one was slight behind but that also was good grade, they told it might catch up.

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This was the first time in my life that I took decision without consulting BH / mom/ mil or anyone,and the decision was made within a minute, I just told, that mentally blastocyst  transfer would be fine for me.Now tomorrow I will know how many have made it to blasts.RE suggested that if I want day 5 transfer then freeze two day 3 embryo which are actually really good,remaining 5 we can let it grow, in case we lose all during the day 5 we have two day 3 back up, so fingers crossed that all five grow on day 5, and I can get done with ET tomorrow, my friend  F told that even her  few d grade embryo grew until day 5, mine was grade b embies so it should grow fine she told, I was nervous after taking the decision she told just go with the flow it will work out. Please pray that my embryos grow and I can have ET tomorrow.

Never Ending ….

DISCLAIMER

Until I start IVF it is never ending reports and meeting the doctors. I knew all this but it feels never ending . I met RE on Monday, seeing my  AMH and BH’s semen analysis she told we’ll do two IUI’s if that does not work we can start IVF, she told this even before seeing my other reports. I told her that both my tubes are blocked , she was like “oh I did not see that”,So its IVF for you she told, I knew that thank you.

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Then she checked my other reports and told everything is fine, but I cant find TB PCR report and discharge summary after Hystro-laparoscopy , sigh. I had to go back to the hospital where my gynecologist did hystro-lap and get both those reports, it’s never ending I must say. When I went to the hospital to take my report first they told I will get the report in  ten minutes then , later they told it will come by evening. then next day never ending did I say.

Next day I called in the morning, they told they will call back in 10 minutes but I never got call until 3 pm, I called them and scolded them. At that time they are telling that if AFP culture, smear , tissue  whatever all the reports are negative/fine means PCR also will be negative so  they don’t test that and I can take back that money, I was relieved but also  irritated with all this, and felt so many hurdles before I start IVF.

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Ok coming back to my meeting with RE, she then explained that I will be starting IVF from second day of my period. They will be doing IVF- ICSI , even though BH’s SA is good. When I asked why? they told the success rate is more in ICSI. Then she told that since my AMH is good I might have chances of OHSS, I was shocked, but was just listening, she told there are Chances of OHSS but I can’t tell it will happen , don’t worry much we will take care of you that’s what she told I think. So maybe it wont be a fresh transfer, we will do FET cycle , but fresh transfer or FET will be know depending upon how my health will be at that time. Then I asked the doctor for IVF many people start with Birth Control Pills(BCP) why she is starting for me from just day 2  , she told that in other clinics they take control of your cycle when there are too many patients, but here we concentrate on less people , so we start with second day of your periods, that’s it.

Then met the finance person, got the details, she explained well . She split the amount for what  is for what and all.The total cost of IVF , plus some MACS test for selecting best sperm for ICSI,  cost for freezing the  embryo for 4 , if there are more than four , again some more thousands of  rupees  sigh, then extra more  money if it is FET cycle . The injections can be taken by the nurse in the clinic she told, if my home is near, so mostly those injection days I  will be going to clinic daily I think so, even though the clinic is just 7 to 8 KM, but in this Bangalore traffic it will take 30 to 45 mins in non peak traffic time, so mostly the timing will be between 11 am to 12 pm noon.

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Then met the in house counselor who spoke very nicely, I felt good. She told me eat good food, not to eat out, walk as much as possible, yoga , pranayama , not to fall sick and in general spoke very nicely made me feel better, she also told I could speak to her if I want to, also there was a infertility talk next day , she told I could come if I want too. I also told about my blog and a India Infertility group me and a friend are trying to start so we can make others feel we are not alone. It was good.

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Tomorrow again I will be meeting  RE again to give the final reports and BH will be giving semen for freezing, he can give fresh semen during egg retrival too, this just for a back up and we are  paying for semen freezing obviously .This  has become a never ending post, hopefully my meeting with RE go fine and I should go next on day 2 of my period for starting IVF.I need your prayers.

 

What next ?

What next is the biggest question I have at this point of time in my life,even though I know  that my doctors  have told IVF is the only option I have right now. I am also preparing for IVF  mentally, Physically and financially, but this waiting game is frustrating.I wonder how people cope with this waiting game, especially when you want something the most but its delayed due to so many factors which are known and unknown to us, so it  makes the waiting more worse than anything in life.

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I met my gynecologist yesterday after a week to remove my stitches, I had to go on Saturday but could not go due to some other reasons.Removal of stitches was ok near the abdomen but near my navel it was a bit painful only for few minutes, it was done by some junior doctor. later my gynec came to meet me where I was lying down after removal of the stitch. As I had told in my last post that both my RE and gynec had discussed that if my right tube is blocked according to my Feb HSG  report and if my right tube was causing any problem for conceiving than to remove the right tube.

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My gynec decided not remove my right tube since both my tubes are fine, only its blocked that’s it, so she decided to tell my RE its not necessary to remove the tube and it wont have any bad effect during IVF.

My meeting with gynec went well, she told  me that my tubes are fine and it can open in future and she spoke to my RE when I was on operation table that its not necessary to remove the tube so I am a bit relived, so my tubes are fine and in my uterus, also I have heard that tubes  usually closes and opens depending on our diet or our Karma or our luck. One of my cousin conceive after eight years on her fourth IVF and conceived naturally next one within two years, her tubes had opened and it was miracle baby two for her.

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OK now if you read until now and wondering why I have that question on what next ?when I know it is IVF, but they have sent my some blood sample,endo lining and smear and what not I  don’t know for testing some

AFB  BACTEA Culture

AFB Smear

AFB Culture 

AFB Culture (Identification)

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Then something specimen source  and smear is sent by tissue and that result is Acid fast Bacilli NOT SEEN its written in the report so that’s fine I think.I know I should be stress free and talk to  about these to my doc but I cant wait. I think here in India they do this test to check to find out genital TB because it will be difficult to conceive or  during IVF embryo wont implant due to TB (this I read in some trying to conceive forum, written  by somebody who  had done these tests during there treatment for infertility)so if its positive they give treatment for three or six months and then when its cured they find out by endo biopsy and start IUI or IVF whatever next. So I will be meeting my gynec to get my report on AFB culture and then will meet my RE to start IVF maybe form October or November. So please pray for me all is fine and I can start with IVF soon.